Regulated intramembrane proteolysis takes another twist.

Huppert S, Kopan R
Dev Cell. 2001 1 (5): 590-2

PMID: 11709178 · DOI:10.1016/s1534-5807(01)00081-8

Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.

MeSH Terms (11)

Animals Cell Membrane Drosophila Drosophila Proteins Epidermal Growth Factor Golgi Apparatus Humans Membrane Proteins Protein Processing, Post-Translational Protein Structure, Tertiary Serine Endopeptidases

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