Molecular genetic analysis of diabetes in mice.

Gannon M
Trends Genet. 2001 17 (10): S23-8

PMID: 11585673 · DOI:10.1016/s0168-9525(01)02453-2

Transgenic and 'knockout' models are increasingly used to study the role of the immune system, insulin signaling and beta-cell gene transcription in diabetes. Mice and humans have similar genetics, developmental biology and physiology. In interpreting these models, however, one needs to be mindful of some differences that exist between mice and humans.

MeSH Terms (14)

Animals Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Disease Models, Animal Humans Insulin Islets of Langerhans Mice Mice, Inbred NOD Mice, Knockout Mice, Obese Mice, Transgenic Molecular Biology Species Specificity

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