Role of co-repressors in transcriptional repression mediated by the t(8;21), t(16;21), t(12;21), and inv(16) fusion proteins.

Hiebert SW, Lutterbach B, Amann J
Curr Opin Hematol. 2001 8 (4): 197-200

PMID: 11561155 · DOI:10.1097/00062752-200107000-00003

The t(8;21), t(16;21), inv(16), and t(12;21) are some of the most frequent chromosomal translocations found in acute myeloid and acute lymphoblastic leukemia. The fusion proteins created by these chromosomal translocations are transcriptional repressors. A full understanding of the types of proteins that these fusion proteins recruit to repress transcription will not only clarify understanding of the molecular mechanism of action of these fusion proteins but also provide further targets for therapeutic intervention.

MeSH Terms (12)

Acute Disease Core Binding Factor Alpha 2 Subunit Gene Expression Regulation, Neoplastic Humans Leukemia, Myeloid Oncogene Proteins, Fusion Precursor Cell Lymphoblastic Leukemia-Lymphoma Repressor Proteins RUNX1 Translocation Partner 1 Protein Transcription, Genetic Transcription Factors Translocation, Genetic

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