Changes in rat cerebral blood volume due to modulation of the 5-HT(1A) receptor measured with susceptibility enhanced contrast MRI.

Scanley BE, Kennan RP, Gore JC
Brain Res. 2001 913 (2): 149-55

PMID: 11549378 · DOI:10.1016/s0006-8993(01)02771-8

Brain blood volume changes in the rat in response to 5-HT(1A) agonist and antagonist administration were measured using susceptibility contrast enhanced magnetic resonance imaging (MRI). Administration of the 5-HT(1A) agonist 8-OH-DPAT resulted in decreases in fractional brain blood volumes. Administration of the 5-HT(1A) antagonist WAY-100635 following a dose of 8-OH-DPAT resulted in increases in fractional blood volumes greatest in hippocampus and cortex and smallest in thalamus and caudate-putamen. The magnitude of the regional increases in blood volumes paralleled the distribution of 5-HT(1A) receptors in the rat brain. Administration of WAY-100635 alone resulted in decreases in cortical blood volume and increases in cerebellar blood volume.

MeSH Terms (21)

8-Hydroxy-2-(di-n-propylamino)tetralin Animals Blood Pressure Blood Volume Brain Cerebrovascular Circulation Contrast Media Dose-Response Relationship, Drug Drug Interactions Female Magnetic Resonance Imaging Neurons Piperazines Pyridines Rats Rats, Sprague-Dawley Receptors, Serotonin Receptors, Serotonin, 5-HT1 Serotonin Serotonin Antagonists Serotonin Receptor Agonists

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