Regulation of Rho GTPases by p120-catenin.

Anastasiadis PZ, Reynolds AB
Curr Opin Cell Biol. 2001 13 (5): 604-10

PMID: 11544030 · DOI:10.1016/s0955-0674(00)00258-1

Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

MeSH Terms (10)

Animals Cadherins Catenins Cell Adhesion Molecules Cell Movement Contact Inhibition Models, Biological Neoplasm Metastasis Phosphoproteins rho GTP-Binding Proteins

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