Genetic differences between adenocarcinomas arising in Barrett's esophagus and gastric mucosa.

El-Rifai W, Frierson HF, Moskaluk CA, Harper JC, Petroni GR, Bissonette EA, Jones DR, Knuutila S, Powell SM
Gastroenterology. 2001 121 (3): 592-8

PMID: 11522743 · DOI:10.1053/gast.2001.27215

BACKGROUND & AIMS - Barrett adenocarcinoma (BA+) and gastric adenocarcinoma comprise a related group of neoplasms that nevertheless have some distinct clinicopathologic characteristics. This study aimed at defining critical molecular abnormalities that may underlie differences between BA+ and gastric adenocarcinomas.

METHODS - We used comparative genomic hybridization for the analyses of 34 xenografts of adenocarcinomas that arose from esophageal or gastric origin.

RESULTS - All tumors, except one, exhibited DNA copy number alterations. Losses in 4q and 14q and gains at 2p and 17q were more frequent in proximal (esophageal, gastroesophageal junction [GEJ], and cardia) tumors than in distal (body and antrum) tumors (P
CONCLUSIONS - Although these adenocarcinomas share some common genetic alterations, the differences in the DNA copy numbers in BA+ cases suggest that unique genetic alterations may be involved in these cancers' development.

MeSH Terms (14)

Adenocarcinoma Animals Barrett Esophagus Carcinoma, Signet Ring Cell Esophageal Neoplasms Gastric Mucosa Gene Dosage Humans Immunocompromised Host Mice Mice, Mutant Strains Neoplasm Transplantation Stomach Neoplasms Transplantation, Heterologous

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