Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.

Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE, Millar SE
Mech Dev. 2001 107 (1-2): 69-82

PMID: 11520664 · DOI:10.1016/s0925-4773(01)00452-x

Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process. We show that expression of Wnts 10b and 10a is upregulated in placodes at the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth. The expression of additional Wnt genes is observed in follicles at later stages of differentiation. Among these, we find that Wnt5a is expressed in the developing dermal condensate of wild type but not Sonic hedgehog (Shh)-null embryos, indicating that Wnt5a is a target of SHH in hair follicle morphogenesis. These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis.

MeSH Terms (19)

Animals Embryonic Induction Gene Expression Profiling Gene Expression Regulation, Developmental Hair Follicle Hedgehog Proteins In Situ Hybridization Mice Morphogenesis Mutation Nerve Tissue Proteins Proto-Oncogene Proteins Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Skin Trans-Activators Up-Regulation Wnt-5a Protein Wnt Proteins

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