Platelets in suspension require preactivation to adhere to immobilized fibrinogen.

Bonnefoy A, Liu Q, Jerome WG, Legrand C, Frojmovic MM
Ann N Y Acad Sci. 2001 936: 459-63

PMID: 11460502 · DOI:10.1111/j.1749-6632.2001.tb03531.x

Previous studies using whole blood perfusion through flow chambers have suggested that unactivated platelets can adhere to surface immobilized fibrinogen (Fg). However, the red blood cells needed for surface delivery of the platelets may activate platelets by released adenosine diphosphate (ADP). Our studies of coaggregation of unactivated or ADP-activated platelets with Fg-coated latex beads in flowing suspensions show that only preactivated platelets can adhere to Fg-coated surfaces.

MeSH Terms (6)

Blood Platelets Cell Adhesion Fibrinogen Humans Microscopy, Electron Platelet Activation

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