A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.

Tahir SK, Han EK, Credo B, Jae HS, Pietenpol JA, Scatena CD, Wu-Wong JR, Frost D, Sham H, Rosenberg SH, Ng SC
Cancer Res. 2001 61 (14): 5480-5

PMID: 11454695

MeSH Terms (21)

Antineoplastic Agents Apoptosis Binding Sites Cell Cycle Cell Cycle Proteins Cell Division Colchicine Drug Interactions Drug Resistance, Multiple G2 Phase Humans Microtubules Mitosis Oxadiazoles Paclitaxel Phosphorylation Proto-Oncogene Proteins c-bcl-2 Time Factors Tubulin Tumor Cells, Cultured Vinblastine

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