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Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.

Turesky RJ, Parisod V, Huynh-Ba T, Langouët S, Guengerich FP
Chem Res Toxicol. 2001 14 (7): 901-11

PMID: 11453738 · DOI:10.1021/tx010035s

MeSH Terms (20)

Amines Animals Biotransformation Cells, Cultured Cytochrome P-450 CYP1A2 Cytochrome P-450 CYP1A2 Inhibitors Enzyme Inhibitors Hepatocytes Humans Inactivation, Metabolic Kinetics Microsomes, Liver Mutagens NADPH-Ferrihemoprotein Reductase Quinoxalines Rats Recombinant Proteins Species Specificity Substrate Specificity Theophylline

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