Functional genomics of the murine immune system.

Ruley HE
Immunol Res. 2001 23 (2-3): 289-99

PMID: 11444394 · DOI:10.1385/IR:23:2-3:289

The mouse and human genome sequences provide new opportunities to characterize mammalian gene functions on a genome-wide level. Toward this end, we have developed strategies for tagged-sequence mutagenesis in mice. Tagged-sequence mutagenesis has been used first, to analyze genes implicated in posttranscriptional gene regulation, and second, to identify genes important in immune cell development and function.

MeSH Terms (32)

Animals B-Lymphocytes DNA Methylation DNA Repair Embryo, Mammalian Expressed Sequence Tags Gene Expression Regulation Gene Library Genes Genes, Lethal Genes, Recessive Genes, Synthetic Gene Targeting Genetic Vectors Genomics Genomics Heterogeneous-Nuclear Ribonucleoproteins Humans Immune System Inflammation Mediators Leukopenia Lymphocyte Activation Mice Mutagenesis, Site-Directed Phenotype Proviruses Retroviridae Ribonucleoproteins Ribonucleoproteins, Small Nucleolar RNA Splicing Species Specificity Stem Cells

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