Immune recognition, response, and regulation: how T lymphocytes do it.

Joyce S
Immunol Res. 2001 23 (2-3): 215-28

PMID: 11444386 · DOI:10.1385/IR:23:2-3:215

Effective immunity to infectious agents requires the initial recognition of antigen by specific receptors, which leads to the activation of immunocytes and the elicitation of an immune response. Because T cell antigen recognition and directed responses are complex processes, they are initiated and quelled in a highly regulated manner. Our laboratory has focused on defining the molecular processes that control T cell antigen presentation and recognition. Research in this area is focused on determining the chemical nature of antigens displayed by Major histocompatibility, complex (MHC)-encoded class I molecules and the nonclassical class I-like protein CD1d. Quantitative aspects of antigen presentation and recognition are also being studied to determine how these factors control the initiation of a T cell response. Our studies provide insights into the biochemical basis of T cell antigen recognition and response as well as the molecular processes underlying the initiation and regulation of immune responses by CD1d-restricted natural T lymphocytes.

MeSH Terms (31)

Amino Acid Sequence Animals Antigen Presentation Antigens, CD1 Antigens, CD1d Antiporters Cytokines Endoplasmic Reticulum Golgi Apparatus H-2 Antigens Histocompatibility Antigens Class I Humans Immune System Immunoglobulins Killer Cells, Natural Ligands Lipids Lymphocyte Activation Membrane Transport Proteins Mice Mice, Knockout Models, Immunological Molecular Sequence Data Protein Conformation Protein Transport Receptors, Antigen, T-Cell Sequence Alignment Sequence Homology, Amino Acid T-Lymphocytes, Cytotoxic T-Lymphocyte Subsets Thymus Gland

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