Transcriptional reprogramming during T helper cell differentiation.

Aune TM
Immunol Res. 2001 23 (2-3): 193-204

PMID: 11444384 · DOI:10.1385/IR:23:2-3:193

Our laboratory employs reporter transgenic mice as model systems to study the transcriptional reprogramming that accompanies T helper cell differentiation. These studies demonstrate that changes in the activity of simple transcriptional elements associated with the IFN-gamma gene can recapitulate alterations in gene expression. In addition, our studies have revealed a key role for the transcription factor, CAMP response element binding protein (CREB), in the protection of differentiating T cells from apoptosis. Together, these findings further our understanding of the logic employed by T cells to alter gene expression profiles in response to differentiation signals.

MeSH Terms (30)

Animals Apoptosis Brain CD8-Positive T-Lymphocytes Cell Differentiation Colforsin Cyclic AMP Cyclic AMP Response Element-Binding Protein Cyclosporine DNA-Binding Proteins Gene Expression Regulation Genes, Reporter Immunologic Memory Immunosuppressive Agents Interferon-gamma Interleukin-4 Interleukin-12 Memory Mice Mice, Transgenic Models, Animal Models, Biological NFATC Transcription Factors Nuclear Proteins Promoter Regions, Genetic Receptors, Antigen, T-Cell Second Messenger Systems T-Lymphocytes, Helper-Inducer Transcription, Genetic Transcription Factors

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