Coordinate regulation of metabotropic glutamate receptors.

Alagarsamy S, Sorensen SD, Conn PJ
Curr Opin Neurobiol. 2001 11 (3): 357-62

PMID: 11399435 · DOI:10.1016/s0959-4388(00)00219-1

Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important determinant in regulating mGluR function and the subsequent neuromodulatory events elicited by activation of mGluRs.

MeSH Terms (16)

Animals Brain Cells, Cultured Cyclic AMP-Dependent Protein Kinases Glutamic Acid Humans Nerve Tissue Proteins Phosphorylation Protein Kinase C Protein Processing, Post-Translational Protein Subunits Receptor Cross-Talk Receptors, Metabotropic Glutamate Receptors, N-Methyl-D-Aspartate Receptors, Presynaptic Signal Transduction

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