Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.

Schroeder MC, Hamby JM, Connolly CJ, Grohar PJ, Winters RT, Barvian MR, Moore CW, Boushelle SL, Crean SM, Kraker AJ, Driscoll DL, Vincent PW, Elliott WL, Lu GH, Batley BL, Dahring TK, Major TC, Panek RL, Doherty AM, Showalter HD
J Med Chem. 2001 44 (12): 1915-26

PMID: 11384237 · DOI:10.1021/jm0004291

MeSH Terms (27)

3T3 Cells Animals Antineoplastic Agents Cell Division Colonic Neoplasms CSK Tyrosine-Protein Kinase Enzyme Inhibitors ErbB Receptors Glioma Humans Indicators and Reagents Kinetics Mice Molecular Conformation Molecular Structure Phosphorylation Protein-Tyrosine Kinases Pyrimidines Rats Receptors, Fibroblast Growth Factor Receptors, Platelet-Derived Growth Factor Recombinant Proteins src-Family Kinases Structure-Activity Relationship Transfection Tumor Cells, Cultured Urea

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