Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.

Ohman T, King SL, Krithivas A, Cunningham J, Dickeson SK, Santoro SA, Bergelson JM
Virus Res. 2001 76 (1): 1-8

PMID: 11376841 · DOI:10.1016/s0168-1702(01)00226-x

Echoviruses (EV) 1 and 8 were originally considered to be distinct serotypes, but more recently have been considered strains of the same virus. In experiments with chimeric recombinant fusion proteins, both viruses bound to the I domain of the integrin VLA-2, and both required the same receptor residues for attachment. A full-length, infectious cDNA clone encoding EV1 was obtained; its nucleotide sequence was determined, as were the sequences encoding the EV8 capsid. EV1 and 8 show 94% amino acid identity within the capsid region and are more similar to each other than to any other human picornavirus.

MeSH Terms (20)

Amino Acid Sequence Animals Binding Sites Capsid Cloning, Molecular DNA, Complementary DNA, Recombinant Enterovirus B, Human HeLa Cells Humans Mice Models, Molecular Molecular Sequence Data Phylogeny Protein Binding Protein Structure, Tertiary Receptors, Very Late Antigen Receptors, Virus Recombinant Fusion Proteins Sequence Homology, Amino Acid

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