Streptokinase triggers conformational activation of plasminogen through specific interactions of the amino-terminal sequence and stabilizes the active zymogen conformation.

Boxrud PD, Verhamme IM, Fay WP, Bock PE
J Biol Chem. 2001 276 (28): 26084-9

PMID: 11369771 · DOI:10.1074/jbc.M101966200

MeSH Terms (8)

Binding Sites Enzyme Precursors Humans Plasminogen Protein Binding Protein Conformation Streptokinase Substrate Specificity

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