Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy.

Wellons MF, Ottinger JS, Weinhold KJ, Gryszowka V, Sanders LL, Edwards LJ, Gooding ME, Thomasch JR, Bartlett JA
J Infect Dis. 2001 183 (10): 1522-5

PMID: 11319689 · DOI:10.1086/320193

A dissociation between plasma human immunodeficiency virus (HIV) RNA levels and CD4(+) cell counts has been reported in patients experiencing viral relapse while receiving antiretroviral therapy. This study compared patients with stable CD4(+) lymphocytes during viral relapse while receiving treatment with patients who had sustained virus suppression. Plasma HIV RNA levels, lymphocyte immunophenotyping, and T cell receptor excision circle (TREC) levels were measured. Naive CD4(+) lymphocyte phenotype and TREC levels were not significantly different in patients with virus suppression or in those who had relapsed. However, CD8(+) lymphocyte activation, including the number and percentage of activated cells and CD38 antibody-binding capacity, was significantly elevated during viral relapse, compared with that in suppressed patients. By multivariable regression analyses, CD8(+) and CD4(+) lymphocyte activation were associated significantly with increasing plasma HIV RNA levels.

MeSH Terms (19)

Adult Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Female Flow Cytometry Gene Rearrangement, T-Lymphocyte HIV HIV Infections Humans Immunophenotyping Lymphocyte Activation Male Middle Aged Recurrence Remission Induction RNA, Viral T-Lymphocyte Subsets

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