Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.

Liu G, Huth JR, Olejniczak ET, Mendoza R, DeVries P, Leitza S, Reilly EB, Okasinski GF, Fesik SW, von Geldern TW
J Med Chem. 2001 44 (8): 1202-10

PMID: 11312920 · DOI:10.1021/jm000503f

MeSH Terms (13)

Allosteric Regulation Amides Animals Cinnamates Combinatorial Chemistry Techniques Intercellular Adhesion Molecule-1 Ligands Lymphocyte Function-Associated Antigen-1 Magnetic Resonance Spectroscopy Models, Molecular Rats Solubility Structure-Activity Relationship

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