Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.

Langou√ęt S, Welti DH, Kerriguy N, Fay LB, Huynh-Ba T, Markovic J, Guengerich FP, Guillouzo A, Turesky RJ
Chem Res Toxicol. 2001 14 (2): 211-21

PMID: 11258970 · DOI:10.1021/tx000176e

MeSH Terms (19)

Animals Biotransformation Cells, Cultured Cell Separation Chromatography, High Pressure Liquid Cytochrome P-450 CYP1A2 Cytochrome P-450 CYP1A2 Inhibitors Enzyme Inhibitors Hepatocytes Humans Inactivation, Metabolic In Vitro Techniques Magnetic Resonance Spectroscopy Mass Spectrometry Microsomes, Liver Mutagens Quinoxalines Rats Theophylline

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