Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

Elson JL, Samuels DC, Turnbull DM, Chinnery PF
Am J Hum Genet. 2001 68 (3): 802-6

PMID: 11179029 · PMCID: PMC1274494 · DOI:10.1086/318801

MeSH Terms (13)

Adult Aging Child DNA, Mitochondrial DNA Replication Founder Effect Gene Frequency Humans Mitochondria Models, Genetic Mutation Oxidative Phosphorylation Probability

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