Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN.

McCollum D, Gould KL
Trends Cell Biol. 2001 11 (2): 89-95

PMID: 11166217 · DOI:10.1016/s0962-8924(00)01901-2

Proper completion of mitosis requires careful coordination of numerous cellular events. It is crucial, for example, that cells do not initiate spindle disassembly and cytokinesis until chromosomes have been properly segregated. Cells have developed numerous safeguards or checkpoints to delay exit from mitosis and initiation of the next cell cycle in response to defects in late mitosis. In this review, we discuss recent work on two homologous signaling pathways in budding and fission yeast, termed the mitotic exit network (MEN) and septation initiation network (SIN), respectively, that are essential for coordinating completion of mitosis and cytokinesis with other mitotic events.

MeSH Terms (13)

Bacterial Proteins Cell Division DNA-Binding Proteins DNA Damage Mitosis Neoplasm Proteins Peptide Elongation Factors Saccharomyces cerevisiae Schizosaccharomyces Signal Transduction Spindle Apparatus Transcriptional Elongation Factors Transcription Factors

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