Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons.

Bianchi L, Miller DM, George AL
Neurosci Lett. 2001 299 (3): 177-80

PMID: 11165764 · DOI:10.1016/s0304-3940(01)01525-7

In this study, we report the complete cDNA sequence, genomic organization and expression pattern of the Caenorhabditis elegans ClC chloride channel gene, clh-6. Two different types of reporter gene fusions suggest that clh-6 expression is restricted to two gamma-aminobutyric acid-ergic RME neurons. These results are in striking contrast with the wide tissue distribution of messenger RNA for the related mammalian isoforms, CIC-6 and CIC-7. The restricted expression pattern of clh-6 provides a unique opportunity to study the biological function of a neuronal CIC chloride channel.

MeSH Terms (19)

Amino Acid Sequence Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Carbocyanines Chloride Channels Cloning, Molecular Fluorescent Dyes gamma-Aminobutyric Acid Gene Expression Regulation Green Fluorescent Proteins Indicators and Reagents Luminescent Proteins Molecular Sequence Data Nervous System Neurons Phylogeny Protein Isoforms Sequence Homology, Nucleic Acid

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