Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains.

Gómez-Duarte OG, Pasetti MF, Santiago A, Sztein MB, Hoffman SL, Levine MM
Infect Immun. 2001 69 (2): 1192-8

PMID: 11160021 · PMCID: PMC98005 · DOI:10.1128/IAI.69.2.1192-1198.2001

Deleting transmembrane alpha-helix motifs from Plasmodium falciparum sporozoite surface protein (SSP-2) allowed its secretion from Salmonella enterica serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908-htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Typhimurium constructs secreting SSP-2 stimulated greater gamma interferon splenocyte responses than did nonsecreting constructs (P = 0.04).

MeSH Terms (14)

Animals Antigens, Protozoan Female Immunization Lymphocyte Activation Malaria Vaccines Mice Mice, Inbred C57BL Molecular Weight Plasmodium falciparum Protozoan Proteins Salmonella T-Lymphocytes, Cytotoxic Vaccines, DNA

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