A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.

Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB
Nat Cell Biol. 2000 2 (12): 915-21

PMID: 11146656 · DOI:10.1038/35046566

Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.

MeSH Terms (21)

Amino Acid Motifs Amino Acid Sequence Animals Apoptosis Base Sequence Caspases Cloning, Molecular COS Cells Cytoskeletal Proteins DNA Primers Enzyme Activation Gene Expression GTP Phosphohydrolases Humans Mitochondria Molecular Sequence Data Septins Sequence Homology, Amino Acid Signal Transduction Transfection Transforming Growth Factor beta

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