Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function.

Buchanan G, Yang M, Harris JM, Nahm HS, Han G, Moore N, Bentel JM, Matusik RJ, Horsfall DJ, Marshall VR, Greenberg NM, Tilley WD
Mol Endocrinol. 2001 15 (1): 46-56

PMID: 11145738 · DOI:10.1210/mend.15.1.0581

MeSH Terms (25)

Adenocarcinoma Androgen Antagonists Androgens Animals Binding Sites Cell Line COS Cells Dihydrotestosterone DNA Estradiol Flutamide Humans Male Mice Mice, Transgenic Models, Molecular Mutagenesis Mutation Progesterone Prostatic Neoplasms Protein Structure, Secondary Receptors, Androgen Structure-Activity Relationship Transcriptional Activation Transfection

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