Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino.

Gonzalez EM, Fekany-Lee K, Carmany-Rampey A, Erter C, Topczewski J, Wright CV, Solnica-Krezel L
Genes Dev. 2000 14 (24): 3087-92

PMID: 11124801 · PMCID: PMC317122 · DOI:10.1101/gad.852400

Spatial variations in the levels of bone morphogenetic protein (BMP) signaling are a critical determinant of dorsoanterior-ventroposterior pattern in vertebrate embryos. Whereas BMP overexpression abolishes both head and trunk development, known single and double loss-of-function mutations in BMP inhibitors have less dramatic effects. We report that combining mutations in the zebrafish genes bozozok and chordino causes a synergistic loss of head and trunk, whereas most cells express ventro-posterior markers and develop into a tail. Genetic inactivation of BMP signaling fully suppresses these defects. Thus, a remarkably simple genetic mechanism, involving a coinhibition of BMP function by the partially overlapping bozozok and chordino pathways is used to specify vertebrate head and trunk.

MeSH Terms (17)

Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Embryo, Nonmammalian Eye Proteins Female Gene Expression Regulation, Developmental Head Homeodomain Proteins Mesoderm Mutation Nerve Tissue Proteins Signal Transduction Tail Zebrafish Zebrafish Proteins

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