Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.

Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T
Mutat Res. 2000 472 (1-2): 129-38

PMID: 11113705 · DOI:10.1016/s1383-5718(00)00138-8

MeSH Terms (16)

Aryl Hydrocarbon Hydroxylases Biotransformation Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A2 Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System Escherichia coli Humans Mutagenicity Tests Mutagens NADPH-Ferrihemoprotein Reductase Pyrenes Recombinant Fusion Proteins Salmonella typhimurium Structure-Activity Relationship Vehicle Emissions

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