Hydrophobic amino acid residues are critical for the immunodominant epitope of the Goodpasture autoantigen. A molecular basis for the cryptic nature of the epitope.

David M, Borza DB, Leinonen A, Belmont JM, Hudson BG
J Biol Chem. 2001 276 (9): 6370-7

PMID: 11098057 · DOI:10.1074/jbc.M008956200

MeSH Terms (12)

Amino Acid Sequence Anti-Glomerular Basement Membrane Disease Autoantibodies Autoantigens Collagen Collagen Type IV Humans Immunodominant Epitopes Molecular Sequence Data Mutagenesis, Site-Directed Protein Folding Structure-Activity Relationship

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