Zebrafish nma is involved in TGFbeta family signaling.

Tsang M, Kim R, de Caestecker MP, Kudoh T, Roberts AB, Dawid IB
Genesis. 2000 28 (2): 47-57

PMID: 11064421 · DOI:10.1002/1526-968x(200010)28:2<47::aid-gene20>3.0.co;2-s

Bone morphogenetic proteins (BMP) are members of the TGFbeta superfamily of secreted factors with important regulatory functions during embryogenesis. We have isolated the zebrafish gene, nma, that encodes a protein with high sequence similarity to human NMA and Xenopus Bambi. It is also similar to TGFbeta type I serine/theronine kinase receptors in the extracellular ligand-binding domain but lacks a cytoplasmic kinase domain. During development, nma expression is similar to that of bmp2b and bmp4, and analysis in the dorsalized and ventralized zebrafish mutants swirl and chordino indicates that nma is regulated by BMP signaling. Overexpression of nma during zebrafish and Xenopus development resulted in phenotypes that appear to be based on inhibition of BMP signaling. Biochemically, NMA can associate with TGFbeta type II receptors and bind to TGFbeta ligand. We propose that nma is a BMP-regulated gene whose function is to attenuate BMP signaling during development through interactions with type II receptors and ligands.

MeSH Terms (25)

Activin Receptors, Type I Amino Acid Sequence Animals Body Patterning Bone Morphogenetic Proteins Embryo, Nonmammalian Female Gene Expression Regulation, Developmental In Situ Hybridization Membrane Proteins Microinjections Molecular Sequence Data Mutation Protein-Serine-Threonine Kinases Radiation Hybrid Mapping Receptor, Transforming Growth Factor-beta Type I Receptor, Transforming Growth Factor-beta Type II Receptors, Transforming Growth Factor beta RNA Sequence Homology, Amino Acid Signal Transduction Xenopus Xenopus Proteins Zebrafish Zebrafish Proteins

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