B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation.

Gregory MA, Xiao Q, Cornwall GA, Lutterbach B, Hann SR
Oncogene. 2000 19 (42): 4886-95

PMID: 11039906 · DOI:10.1038/sj.onc.1203851

The myc family of genes plays an important role in several cellular processes including proliferation, apoptosis, differentiation, and transformation. B-myc, a relatively new and largely unstudied member of the myc family, encodes a protein that is highly homologous to the N-terminal transcriptional regulatory domain of c-Myc. Here, we show that high level B-myc expression is restricted to specific mouse tissues, primarily hormonally-controlled tissues, with the highest level of expression in the epididymis. We also report the identification of the endogenous B-Myc protein from mouse tissues. Like other Myc family proteins, B-Myc is a short-lived nuclear protein which is phosphorylated on residues Ser-60 and Ser-68. Rapid proteolysis of B-Myc occurs via the ubiquitin-proteasome pathway. Finally, we found that overexpression of B-Myc significantly slows the growth of Rat la fibroblasts and COS cells suggesting B-Myc functions as an inhibitor of cellular proliferation.

MeSH Terms (35)

Adrenal Glands Animals Brain Cell Division Cell Nucleus Cercopithecus aethiops COS Cells Cysteine Endopeptidases DNA, Complementary Epididymis Female Fibroblasts Gene Expression Regulation Genes, myc Growth Inhibitors Hormones Male Mammary Glands, Animal Mice Multienzyme Complexes Nerve Tissue Proteins Organ Specificity Ovary Phosphorylation Pituitary Gland Prostate Proteasome Endopeptidase Complex Protein-Serine-Threonine Kinases Protein Processing, Post-Translational Proto-Oncogene Proteins c-myc Rats Recombinant Fusion Proteins Transfection Ubiquitins Uterus

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