Cyclooxygenase mechanisms.

Marnett LJ
Curr Opin Chem Biol. 2000 4 (5): 545-52

PMID: 11006543 · DOI:10.1016/s1367-5931(00)00130-7

Several advances have occurred in the past year in our understanding of cyclooxygenase catalysis. The role of specific heme oxidation states in the formation of catalytically competent tyrosyl radicals has been defined; the identity of physiological hydroperoxide activators has been established; and the participation of individual amino acids in substrate binding and oxygenation has been elucidated.

MeSH Terms (6)

Arachidonic Acid Binding Sites Heme Oxidants Prostaglandin-Endoperoxide Synthases Substrate Specificity

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