Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1.

Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ
Cancer Res. 2000 60 (17): 4864-8

PMID: 10987299

MeSH Terms (17)

Adaptor Proteins, Signal Transducing Carrier Proteins Colorectal Neoplasms DNA, Neoplasm DNA Methylation DNA Repair Gene Expression Regulation, Neoplastic Gene Silencing Humans Immunohistochemistry Inflammatory Bowel Diseases Microsatellite Repeats MutL Protein Homolog 1 Neoplasm Proteins Nuclear Proteins Polymerase Chain Reaction Promoter Regions, Genetic

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