Natural killer cells determine the outcome of B cell-mediated autoimmunity.

Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG
Nat Immunol. 2000 1 (3): 245-51

PMID: 10973283 · DOI:10.1038/79792

Natural killer (NK) cells can affect the outcome of adaptive immune responses. NK cells, but not NK1.1+T cells, were found to participate in the development of myasthenia gravis (a T cell-dependent, B cell- and antibody-mediated autoimmune disease) in C57BL/6 mice. The requirement for NK cells was reflected by the lack of a type I helper T cell response and antibodies to the acetylcholine receptor in both NK1.1+ cell-depleted and NK cell-deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells.

MeSH Terms (21)

Amino Acid Sequence Animals Antibody Formation Autoantibodies Autoimmunity B-Lymphocytes Female Immunization Inbreeding Interferon-gamma Interleukin-8 Killer Cells, Natural Lymphocyte Activation Mice Mice, Inbred C57BL Molecular Sequence Data Myasthenia Gravis, Autoimmune, Experimental Receptors, Nicotinic T-Lymphocytes Torpedo Transforming Growth Factor beta

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