Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.

Kalgutkar AS, Marnett AB, Crews BC, Remmel RP, Marnett LJ
J Med Chem. 2000 43 (15): 2860-70

PMID: 10956194 · DOI:10.1021/jm000004e

MeSH Terms (16)

Animals Anti-Inflammatory Agents, Non-Steroidal Cell Line Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Humans Indomethacin Isoenzymes Macrophages Membrane Proteins Mice Prostaglandin-Endoperoxide Synthases Sheep Structure-Activity Relationship

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