The structural basis for in situ activation of DNA alkylation by duocarmycin SA.

Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ
J Mol Biol. 2000 300 (5): 1195-204

PMID: 10903864 · DOI:10.1006/jmbi.2000.3887

MeSH Terms (17)

Alkylating Agents Alkylation Antibiotics, Antineoplastic Base Sequence Binding Sites DNA Adducts Duocarmycins Indoles Kinetics Models, Molecular Molecular Conformation Nuclear Magnetic Resonance, Biomolecular Oligodeoxyribonucleotides Pyrroles Stereoisomerism Structure-Activity Relationship Thermodynamics

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