The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins.

Uddin S, Lekmine F, Sharma N, Majchrzak B, Mayer I, Young PR, Bokoch GM, Fish EN, Platanias LC
J Biol Chem. 2000 275 (36): 27634-40

PMID: 10878008 · DOI:10.1074/jbc.M003170200

MeSH Terms (18)

DNA-Binding Proteins Enzyme Inhibitors Humans Imidazoles Interferon-alpha Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases Phosphorylation Phosphoserine Pyridines rac1 GTP-Binding Protein Signal Transduction STAT1 Transcription Factor STAT3 Transcription Factor Trans-Activators Transcription, Genetic Transcriptional Activation Tumor Cells, Cultured

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