Molecular signaling in uterine receptivity for implantation.

Paria BC, Lim H, Das SK, Reese J, Dey SK
Semin Cell Dev Biol. 2000 11 (2): 67-76

PMID: 10873704 · DOI:10.1006/scdb.2000.0153

Successful implantation is the result of an intimate 'cross-talk' between the blastocyst and uterus in a temporal and cell-specific manner. Thus, both the uterine and embryonic events must be examined to better understand this process. Although various aspects and molecules associated with these events have been explored, a comprehensive understanding of the implantation process is still very limited. In this review, we have highlighted the importance of the blastocyst's activity state and the receptive state of the uterus in determining the 'window' of implantation. In this context, we provide a testable scheme that signifies the important roles of various key molecules in embryo-uterine interactions during implantation.

Copyright 2000 Academic Press.

MeSH Terms (18)

Animals Blastocyst Cell Communication Cyclooxygenase 2 Embryo Implantation Epidermal Growth Factor Estrogens Estrogens, Catechol Female Humans Isoenzymes Membrane Proteins Mice Progesterone Prostaglandin-Endoperoxide Synthases Prostaglandins Signal Transduction Uterus

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