Allergic disorders and the risk of childhood acute lymphoblastic leukemia (United States).

Wen W, Shu XO, Linet MS, Neglia JP, Potter JD, Trigg ME, Robison LL
Cancer Causes Control. 2000 11 (4): 303-7

PMID: 10843442 · DOI:10.1023/a:1008958724739

OBJECTIVES - To test the hypothesis that childhood acute lymphoblastic leukemia (ALL) is associated with allergic disorders.

METHODS - We compared the histories of selected allergic disorders (asthma, hay fever, food or drug allergies, eczema, and hives) of 1842 cases of ALL with those of 1986 individually matched controls. The histories of the allergic disorders among siblings of cases and controls were also compared.

RESULTS - The combined history of any one or more of the five allergic disorders evaluated was associated with a significant reduced risk of ALL (adjusted OR = 0.7, 95% CI 0.6-0.8), as were histories of four specific allergic disorders (asthma, hay fever, food or drug allergies, and eczema). The combined history of any one or more of the five allergic disorders among any of the siblings of the study subjects also revealed a significantly inverse association (adjusted OR = 0.9, 95% CI 0.8-1.0).

CONCLUSION - The results from this study, in agreement with most previous studies on adult cancer, suggest that allergic disorders may be associated with a reduced risk of childhood ALL.

MeSH Terms (16)

Adult Case-Control Studies Child Child, Preschool Female Humans Hypersensitivity Infant Logistic Models Male Maternal Age Maternal Exposure Odds Ratio Precursor Cell Lymphoblastic Leukemia-Lymphoma Risk Factors United States

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