Chronic caloric restriction alters muscle membrane fatty acid content.

Cefalu WT, Wang ZQ, Bell-Farrow AD, Terry JG, Sonntag W, Waite M, Parks J
Exp Gerontol. 2000 35 (3): 331-41

PMID: 10832054

Chronic caloric restriction (CR) has been demonstrated to increase longevity in lower species and studies are ongoing to evaluate its effect in higher species. A consistent metabolic feature of CR is improved insulin sensitivity and lowered lifetime glycemia, yet the mechanism responsible is currently unknown. However, the membrane's physiochemical properties, as determined by phospholipid composition, have been related to insulin action in animal and human studies and CR has been reported to alter membrane lipid content. We evaluated muscle membrane fatty acid content in rodents randomized to CR versus control diets for up to 29 months. CR was observed to increase the membrane content of C22:6 (docosahexaenoate) and to decrease C18:2 content. The membrane lipid content was related to insulin levels but not to parameters assessing glycemic control. This study suggests that membrane lipids, in particular 22:6, may contribute to the variation in insulin sensitivity seen with age.

MeSH Terms (17)

Animals Energy Intake Fatty Acids Female Food Deprivation Glucose Transporter Type 4 Humans Insulin Insulin Resistance Longevity Membrane Fluidity Membrane Lipids Monosaccharide Transport Proteins Muscle Proteins Myocardium Rats Rats, Inbred BN

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