NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Huth JR, Olejniczak ET, Mendoza R, Liang H, Harris EA, Lupher ML, Wilson AE, Fesik SW, Staunton DE
Proc Natl Acad Sci U S A. 2000 97 (10): 5231-6

PMID: 10805782 · PMCID: PMC25811 · DOI:10.1073/pnas.97.10.5231

MeSH Terms (19)

Allosteric Site Amino Acid Substitution Animals Binding Sites CD18 Antigens Cell Adhesion COS Cells Crystallography, X-Ray Humans Intercellular Adhesion Molecule-1 Ligands Lymphocyte Function-Associated Antigen-1 Macrophage-1 Antigen Models, Molecular Mutagenesis, Site-Directed Nuclear Magnetic Resonance, Biomolecular Protein Structure, Secondary Recombinant Proteins Transfection

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