Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.

Herrera PL
Development. 2000 127 (11): 2317-22

PMID: 10804174

To analyze cell lineage in the pancreatic islets, we have irreversibly tagged all the progeny of cells through the activity of Cre recombinase. Adult glucagon alpha and insulin beta cells are shown to derive from cells that have never transcribed insulin or glucagon, respectively. Also, the beta-cell progenitors, but not alpha-cell progenitors, transcribe the pancreatic polypeptide (PP) gene. Finally, the homeodomain gene PDX1, which is expressed by adult beta-cells, is also expressed by alpha-cell progenitors. Thus the islet alpha- and beta-cell lineages appear to arise independently during ontogeny, probably from a common precursor.

MeSH Terms (18)

Animals Cell Differentiation Cell Lineage Female Gene Expression Glucagon Homeodomain Proteins Humans Insulin Islets of Langerhans Male Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Pancreatic Polypeptide Stem Cells Trans-Activators

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