Evaluation of ristocetin-Willebrand factor assay and ristocetin-induced platelet aggregation.

Olson JD, Brockway WJ, Fass DN, Magnuson MA, Bowie EJ
Am J Clin Pathol. 1975 63 (2): 210-8

PMID: 1078748 · DOI:10.1093/ajcp/63.2.210

Normal subjects, patients with various bleeding disorders, and patients with von Willebrand's disease were studied. All patients with von Willebrand's disease had decreased levels of ristocetin-Willebrand factor (range, 0 to 41%) as compared with all other subjects (range, 79 to 202%). Ristocetin-induced platelet aggregation of platelet-rich plasma was abnormal in all patients with von Willebrand's disease tested, and it was possible to correct this abnormal response by addition of normal platelet-poor plasma. Abnormal ristocetin-induced platelet aggregation was seen in patients with intrinsic platelet disorders or, on some occasions, in normal patients who had ingested aspirin. Ristocetin-induced platelet aggregation is not diagnostic, but it may be useful as a simple screening test for patients with possible von Willebrand's disease. In conjunction with other tests, the assay for ristocetin-Willebrand factor will be useful in diagnosis and evaluation of these patients.

MeSH Terms (11)

Anticoagulants Antigens Blood Coagulation Disorders Blood Coagulation Factors Blood Platelets Factor VIII Humans Platelet Adhesiveness Platelet Aggregation Ristocetin von Willebrand Diseases

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