Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.

Plastaras JP, Guengerich FP, Nebert DW, Marnett LJ
J Biol Chem. 2000 275 (16): 11784-90

PMID: 10766802 · DOI:10.1074/jbc.275.16.11784

MeSH Terms (16)

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animals Catalysis Cells, Cultured Chromatography, Thin Layer Cytochrome P-450 Enzyme System Fatty Acids, Unsaturated Heme Humans Malondialdehyde Microsomes, Liver Mutagens Prostaglandin Endoperoxides Prostaglandin H2 Prostaglandins H Rabbits

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