Relationship of cognitive functioning, whole brain volumes, and T2-weighted hyperintensities in neurofibromatosis-1.

Cutting LE, Koth CW, Burnette CP, Abrams MT, Kaufmann WE, Denckla MB
J Child Neurol. 2000 15 (3): 157-60

PMID: 10757470 · DOI:10.1177/088307380001500303

Using quantitative magnetic resonance imaging morphometry, we report that the whole brain volumes of patients with neurofibromatosis-1 are significantly larger than normal, confirm the prevalence of macrocephaly as about 50%, and report that macrocephaly in patients with neurofibromatosis-1 does not appear to be related to the familial or sporadic origin of the neurofibromatosis-1 or to the presence or absence of T2-weighted hyperintensities. No strong relationship emerged between the extent of neurofibromatosis-1-associated impairment of cognitive functions and degree of macrocephaly; however, the macrocephalic neurofibromatosis-1 group did have a significant verbal impairment relative to the nonmacrocephalic neurofibromatosis-1 group in vocabulary (P < .009).

MeSH Terms (13)

Adolescent Brain Brain Neoplasms Cephalometry Child Humans Intelligence Language Development Disorders Magnetic Resonance Imaging Male Neurofibromatosis 1 Reference Values Wechsler Scales

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