A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.

Odom AR, Stahlberg A, Wente SR, York JD
Science. 2000 287 (5460): 2026-9

PMID: 10720331 · DOI:10.1126/science.287.5460.2026

Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6, was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.

MeSH Terms (18)

Amino Acid Sequence Arginine Cell Nucleus DNA-Binding Proteins Gene Expression Regulation, Fungal Inositol 1,4,5-Trisphosphate Inositol Phosphates Minichromosome Maintenance 1 Protein Molecular Sequence Data Phosphoric Monoester Hydrolases Phosphorylation Phosphotransferases (Alcohol Group Acceptor) Phytic Acid Saccharomyces cerevisiae Signal Transduction Transcription, Genetic Transcription Factors Type C Phospholipases

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