Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity.

Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM, Shawver LK, Arteaga CL
J Biol Chem. 2000 275 (10): 6987-95

PMID: 10702262 · DOI:10.1074/jbc.275.10.6987

MeSH Terms (19)

Animals Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p27 Cyclin D1 ErbB Receptors Female G1 Phase Humans Mice Mice, Inbred BALB C Microtubule-Associated Proteins Mitogen-Activated Protein Kinase Kinases Phosphoinositide-3 Kinase Inhibitors Phosphorylation Quinazolines Retinoblastoma Protein Tumor Suppressor Proteins Tyrphostins Up-Regulation

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