Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.

Rowlinson SW, Crews BC, Goodwin DC, Schneider C, Gierse JK, Marnett LJ
J Biol Chem. 2000 275 (9): 6586-91

PMID: 10692466 · DOI:10.1074/jbc.275.9.6586

MeSH Terms (17)

Acetylation Animals Arachidonic Acid Aspirin Binding Sites Chromatography, High Pressure Liquid Cyclooxygenase 1 Cyclooxygenase 2 Hydroxyeicosatetraenoic Acids Isoenzymes Membrane Proteins Mice Models, Molecular Mutagenesis, Site-Directed Prostaglandin-Endoperoxide Synthases Prostaglandins Spodoptera

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