Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.

Ober C, Leavitt SA, Tsalenko A, Howard TD, Hoki DM, Daniel R, Newman DL, Wu X, Parry R, Lester LA, Solway J, Blumenthal M, King RA, Xu J, Meyers DA, Bleecker ER, Cox NJ
Am J Hum Genet. 2000 66 (2): 517-26

PMID: 10677312 · PMCID: PMC1288105 · DOI:10.1086/302781

After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one novel variant, representing all nonsynonymous substitutions in the mature protein, were examined in the Hutterites; on the basis of studies in the Hutterites, outbred white, black, and Hispanic families were genotyped for selected markers. All population samples showed evidence of association to atopy or to asthma (P values.039-.0044 for atopy and. 029-.0000061 for asthma), but the alleles or haplotypes showing the strongest evidence differed between the groups. Overall, these data suggest that the IL4RA gene is an atopy- and asthma-susceptibility locus but that variation outside the coding region of the gene influences susceptibility.

MeSH Terms (22)

Alleles Asthma Child Christianity Chromosomes, Human, Pair 16 DNA Mutational Analysis Ethnic Groups Family Health Female Gene Frequency Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Hypersensitivity, Immediate Linkage Disequilibrium Male Molecular Sequence Data Phenotype Polymorphism, Single Nucleotide Receptors, Interleukin-4 United States

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