Discovery of a new class of selective cyclooxygenase-2 (COX-2) inhibitor that covalently modifies the isozyme.

Kalgutkar AS, Crews BC, Rowlinson SW, Garner C, Marnett LJ
Adv Exp Med Biol. 1999 469: 139-43

PMID: 10667322 · DOI:10.1007/978-1-4615-4793-8_21

MeSH Terms (18)

Acetylene Alkynes Animals Anti-Inflammatory Agents, Non-Steroidal Aspirin Catalytic Domain Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Humans In Vitro Techniques Isoenzymes Mass Spectrometry Membrane Proteins Prostaglandin-Endoperoxide Synthases Sheep Structure-Activity Relationship Sulfides

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